Recent Changes
- BroEndocrinology . . . May 17, 2020, at 11:10 PM by phaedrus: ! Obesity This is because the normal pattern of weight gain might not be to slowly accumulate very small amounts each day, but rather to be weight stable for protracted periods, interspersed with periods of gross imbalance during which most weight gain occurs. For example, weight gain during the holiday season in the United States (from Thanksgiving in November until the new year) is significantly higher than during the rest of the year (Yanovski et al., 2000) and is matched by seasonal variation in food intake (de Castro, 1991), although other studies have shown no change in overall weight but an increase in fatness over the same period (Hull et al., 2006). ... The UK Department of Health, for example, recently convened an expert working group to quantify the magnitude of weight change and energy imbalance in the UK population, concluding that the average weight gain was 6.7 kg [14.8 lbs] over 10 years and that the daily energy imbalance necessary to generate this was about 25 kJ/day. The conclusion that is often drawn from these weight gain and energy balance calculations is that our bodies must therefore contain an exquisitely tuned system that controls our intake and expenditure with incredible precision to maintain our body mass at an almost constant level. From a treatment perspective, it is probably this tuning system that has made the pharmacotherapy of obesity such a challenge with regards to efficacy. [[https://dmm.biologists.org/content/4/6/733 | source]] !! Leptin